TiO2 as an Efficient Catalytic Surface for Reduction of Carbonyl Compounds with NaBH4 under Solvent-free, Solid-gel and Microwave Irradiation
Department of Chemistry, Faculty of Sciences, Mahabad Branch, Islamic Azad University, Mahabad, 59135-443 (Iran).
Corresponding Author E-mail: davood.setamdideh@gmail.com
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Structurally different carbonyl compounds such as aldehydes, ketones, a,b-unsaturated enals and enones, a-diketones and acyloins were reduced efficiently by NaBH4/TiO2 system under solvent-free, solid-gel and microwave irradiation. The chemoselective reduction of aldehydes over ketones was achieved successfully by NaBH4/TiO2 system at solvent-free condition. In addition, regioselectivity and exclusive 1,2-reduction of conjugated carbonyl compounds to their corresponding allylic alcohols in high to excellent yields was accomplished successfully with this reducing system.
KEYWORDS:NaBH4; TiO2; Solvent-free; Solid-gel; Microwave
