Lanthanum Nitrate- Catalyzed Synthesis of New 2, 3-dihydro-1, 5-Benzothiazepines


Asgar Jafar khan¹* and Mohammad A. Baseer²

¹Laboratory of Organic Synthesis, Milliya College, Beed - 431 122 (India).

²Organic Chemistry Research Laboratory, Yeshwant Mahavidyalaya, Nanded - 431 602 (India).

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ABSTRACT:

Simple and convenient procedure have been developed for the synthesis of optically active1,5-benzothiazepine derivatives  by reaction of 2-aminothiophenolwith newly synthesized Chalcones under mild conditions in the presence of catalytic amount of Lanthanum Nitrate  in short reaction time with excellent yield(75-80%)The products were tested for purity by TLC and characterized by M.P, IR and 1H NMR spectral studies.

KEYWORDS:

Lanthanum Nitrate; 1, 5-Benzothiazepines; 2-Aminothiophenol; Chalcones; Mild Conditions


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