Poly Phosphoric Acid Impregnated on Silica Gel (PPA-SiO2): A Versatile and Reusable Catalyst for the Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles under Solvent-free and Microwave Irradiation Conditions

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Poly Phosphoric Acid Impregnated on Silica Gel (PPA-SiO2): A Versatile and Reusable Catalyst for the Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles under Solvent-free and Microwave Irradiation Conditions

Naser Montazeri*, Khalil Pourshamsian,Marjan Khoddadi and Kazem Khoddadi

Department of Chemistry, Tonekabon Branch, Islamic Azad University, Tonekabon (Iran).

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ABSTRACT:

A remarkable acceleration in the synthesis of 1,2,4,5-tetrasubstituted imidazoles catalyzed by silica gel supported poly phosphoric acid in high yields under solvent-free and microwave irradiation conditions, with very short reaction time is described. This methodology offers momentous improvements over various options for the synthesis of 1,2,4,5-tetrasubstituted imidazoles with regard to yield of produces, simplicity in operation and green aspects by avoiding toxic catalysts and solvents.

KEYWORDS:

Tetrasubstituted imidazole; PPA-SiO2; solvent-free conditions; Multi-component reaction; Microwave irradiation