Design of Modified Electro-Spun Poly Urethane Nanofiber Film using Chemical Method
1Department of Chemistry, Tonekabon Branch , Islamic Azad University, Tonekabon (Iran).
2Department of Biomedical Engineering , Science and Research Branch Islamic Azad University, Tehran (Iran).
3Clinical Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran (Iran).
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Tissue engineering is defined as the designing and engineering of structures to rebuild and repair a body damaged tissue. Scaffolding Poly urethane (PU) has shown good biocompatibility and biodegradable properties. Nanofibers have improved the performance of biomaterials, and could be considered effective. One of the important methods for designing nanofiber scaffold is the electrospinnig method. In this study, PU nanofibers were well designed; then, modified with the immobilized gelatin via the chemically method. The samples were evaluated by ATR-FTIR, SEM, contact angle. ATR-FTIR structural analysis showed the presence of gelatin on the nanofiber surfaces. The SEM images showed the size average of nanofibers as to be about 300 nm; that increased with a gelatin coating up to 500 nm. Contact angle analysis showed 63 degree for uncoated nanofibers and 41 degree for coated nanofibers. In this work, the PU nanofibers with a size average about 300 nm were designed. Nanofibers were successfully coated with gelatin via the chemically methods. These gelatin-coated nanofibers could be used well for tissue engineering.
KEYWORDS:PU; Surface modification; Nanofiber; Gelatin Coating
