Synthesis, Spectral and Antimicrobial Screening of Schiff Base Complexes Derived from 2 Phenyl- 3 Carboxy Methyl Quinazoline (3H) 4-one

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Synthesis, Spectral and Antimicrobial Screening of Schiff Base Complexes Derived from 2 Phenyl- 3 Carboxy Methyl Quinazoline (3H) 4-one

Kumar Rajeev Kishore^¹ and B.K. Rai^²*

^¹Research Scholar, Department of Chemistry, B. R. A. Bihar University, Muzaffarpur India. ^²Department of Chemistry, LNT College, Muzaffarpur - 842 002 India.

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ABSTRACT:

Complexes of cobalt(II), nickel(II) and copper(II) with a Schiff base, 2 phenyl- 3 carboxy methyl quinazoline (3H) 4- thiosemicarbazone (PCMQT) have been synthesized. The ligand as well as complexes were characterized by the elemental analyses, molar mass, molar conductance, IR, electronic spectra and magnetic susceptibility measurements. All the complexes are non electrolytic in nature. From the analytical and spectroscopic investigation the stoichiometry of the complexes has been found to be [M(PCMQT)2X2] where M = Co(II), Ni(II) and Cu(II); PCMQT = ligand, X = Cl-, Br-, I- and NO3-. On the basis of above observations the geometry of the complexes is proposed to be octahedral in nature. The antimicrobial activities of the ligand and its complexes have been screened against bacteria E. coli and fungi Aspergillus niger.

KEYWORDS:

PCMQT; Schiff base; Complex; Antibacterial; Antifungal