Synthesis and Characterization of New Series of Imidazolidin-2,4-Dione Derivatives and its Antimicrobial Activity

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Synthesis and Characterization of New Series of Imidazolidin-2,4-Dione Derivatives and its Antimicrobial Activity

R. Surendra Kumar^¹, A. Idhayadhulla^¹, A. Jamal Abdul Nasser^¹* and J. Selvin^²

^¹P.G and Research Department of Chemistry, Jamal Mohamed College,Tiruchirappalli - 620 020 India.

^²Department of Microbiology, Bharathidasan University. Tiruchirappalli - 620 024, India.

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ABSTRACT:

The synthesis of compound (2) was achieved using cyclization method of compound (1) with ethyl chloro acetate and fused sodium acetate. Compound (2) was underwent mannich reaction to give compound (3a-3f). The Chemical structures were elucidated by IR, 1 HNMR, and elemental analysis. The compounds (2) and (3a-3f) have been screened for in vitro antimicrobial action against various strains of bacterial and fungi.Imidazolidin-2, 4-dione, mannich base, antimicrobial activity.

KEYWORDS:

Imidazolidin-2; 4-dione; mannich base; antimicrobial activity