Validated Spectrophotometric Estimation of Esomeprazole using Hydrotrophic Solubilisation Technique

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A Simple, accurate and reproducible spectrophotometric method by Hydrotrophic Solubilisation was developed for the estimation of Esomeprazole. In the present investigation, hydrotropic solution of urea (10M) was employed as a solubilising agent to solubilise the poorly water soluble drug, esomeprazole in the tablet form and determined with the help of spectrophotometric determination in ultraviolet region. Esomeprazole showed maximum absorption at 301 nm and obeyed Beer’s law in concentration range of 10-50μg/ml. Statistical analysis of the result has been carried out revealing high accuracy and good precision.

Esomeprazole; hydrotropy; spectrophotometry; urea