Synthesis Characterization and Pharmacological Activity of Novel Thiazolidin – 4 one Analogues

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A new series of 4-oxo-thiazolidines (3a1-3a6) were prepared by reacting Sulphadiazine with substituted aldehydes in alcohol medium in presence of strong base. The resulted Schiff’s base undergoes cyclization with mercapto acetic acid and mercapto succinic acid to yield 4-oxo-thiazolidines (3b1-3b6) The structure of the final synthesized compounds were confirmed by IR, 1H-NMR and MASS spectral technique. The title compounds were screened for their analgesic, anticonvulsant and antibacterial activities.

4-oxo-thiazolidines; Schiff’s base; Analgesic activity; Anticonvulsant activity; Antimicrobial activity