Synthesis and in vitro anticancer activity of some organotin(IV) benzoate compounds

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We have prepared a series of dibutyl-, diphenyl- and triphenyltin(IV) benzoate compounds by the reaction of the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with benzoic acid. The compounds synthesized were characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies, and are based on the microanalytical data. The in vitro activity showed that triphenyltin(IV) benzoate synthesized exhibit higher antitumor than those of dibutyltin(IV) and diphenyltin(IV) analogous.

Synthesis; organotin(IV) benzoate; anticancer