Spectrophotometric methods for the determination of Rosuvastatin

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Three simple and sensitive spectrophotometric methods have been developed for the estimation of Rosuvastatin in bulk and pharmaceutical dosage forms. Method A is based on oxidation followed by complex formation of the drug with 2, 5 dihydroxy 3, 6 dichloro 1, 4 benzoquinone (chloralinic acid λmax 530 nm). The absorbance of the colored species is measured against the corresponding reagent blank at 530nm. Method B is based on salt formation of the drug with picric acid (λmax 440nm). Method C is based on oxidation followed by complex formation of the drug with potassium permanganate (KMnO4 λmax 410nm). These methods have been statistically evaluated and found to be precise and accurate.

Spectrophotometric; Rosuvastatin