Spectrophotometric method for the determination of amorolfine

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Two simple and sensitive spectrophotometric methods have been developed for the estimation of Amorolfine (AMF) in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with 3-methyl 2-benzothiazolinone hydrazone(MBTH λmax 660 nm). The absorbance of the colored species is measured against the corresponding reagent blank. Method B is based on oxidation followed by complex formation when the drug reacts with ferric chloride and 1,10- phenanthroline (λmax 510nm) .These methods have been statistically evaluated and found to be precise and accurate.

Spectrophotometry, Amorolfine, pharmaceutical dosage form.