In vitro and in vivo antiplasmodial activity of oxyresveratrol and artonine isolated from two Artocarpus plants in Indonesia

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In vitro and in vivo antiplasmodial activity of oxyresveratrol and artonine isolated from two Artocarpus plants in Indonesia

Tati Suhartati¹, Yandri¹, Jhons F. Suwandi² And Sutopo Hadi¹*

¹Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Bandar Lampung 35145 (Indonesia) ²Study Program of Medicine, University of Lampung, Bandar Lampung 35145 (Indonesia).

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ABSTRACT:

Antiplasmodial activity of two compounds, oxyresveratrol and artonin E isolated from A. dadah and A. rigida, respectively, were evaluated. The in vitro antiplasmodial activity was done on the chloroquine-resistant strain of P. falciparum 3D7, while the in vivo antiplasmodial assay was done on Swiss mice breed which were infected by P. berghei. The two compounds tested showed very high in vitro activity with IC50 value of 0.05 and 0.2 µg/mL for oxyresveratrol and artonin E, respectively. However, by contrast in the in vivo activity assay, oxyresveratrol has an ED50 of 10.26 mg/kg, while the artonin E was not able to be determined.

KEYWORDS:

A. dadah; A. rigida; antiplasmodial activity; oxyresveratrol; artonin E