A Facile Solvent free Microwave Induced Synthesis of Chlorine Containing Pyrazoline and Isoxazoline Derivatives and their Phytotic Impact on Some Flowering Plants And Antimicrobial Activity

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Eight New chlorine containing 4-Aroyl/Alkoyl-D2-pyrazolines and isoxazolines have been synthesized with 80-85% yield by a microwave promoted solvent-free condensation of 3-aroyl/alkoylflavanones 5a-d respectively with phenylhydrazine hydrochloride and hydroxylaminehydrochloride over potassium carbonate The work-up is simple and involves treatment with ice-cold water. A considerable increase in the reaction rate has been observed, with better yields.

Pyrazolines; Isoxazolines solid-phase synthesis; condensation flavanones; microwaves effect