Synthesis, Characterization and Biological Evaluation of 3-Alkyl-5(4-Substituted Benzene Disulphonamido)-1, 2-Benzisoxazoles and its Derivatives

Shivaji Jadhav; Megha Jadhav; Ayesha Durrani; U.K. Asema, Ayesha Meraj; Hajera Begum

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Synthesis, Characterization and Biological Evaluation of 3-Alkyl-5(4-Substituted Benzene Disulphonamido)-1, 2-Benzisoxazoles and its Derivatives

Shivaji Jadhav*, Megha Jadhav, Ayesha Durrani, U.K. Asema, Ayesha Meraj and Hajera Begum

Department of Chemistry, Maulana Azad College, Dr. Rafiq Zakaria College for Women, Aurangabad - 431 001 (India)

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ABSTRACT:

The chlorosulphonic acid treated with 3-alkylbenzisoxazole to give [1A – 9A] which is concentrated with ammonia solution and further acidified with dil. H2SO4 we get sulphonamido derivatives [1B – 9B] which is on substituted with benzene sulphonyl chloride and pH adjusted to 10-11 by 50% NaOH solution to give Disulphonamido derivatives [1C-27°C]. The synthesized compounds characterized by spectral analysis like IR, NMR and Elemental Analysis. The synthesized compound screened by antibacterial activity.

KEYWORDS:

Chlorosulphonic acid; substituted Benzisoxazole; NH3; dil. H2SO4, NaOH sulphonamido; antibacterial activity