One Pot Synthesis of 3, 4-Dihydropyrimidin – 2(1H) – Ones Catalyzed by Aluminium Sulphate: an Improved Procedure for the Biginelli Reaction

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A simple effective synthesis of 3, 4-dihydropyrimidin-2(1H)-one/thione derivatives using Aluminium sulphate (Al2 (sO4)3.18H2O) catalyst from aromatic aldehydes, 1, 3-dicarbonyl compounds & (thio)urea in glacial acetic acid is described. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yield and short reaction time.

Biginelli reaction; 3; 4-dihydropyrimidin-2(1H)-ones; Aluminium sulphate; Condensation reaction; multicomponent reaction