Hydroxamic Acid as Anticancer Agent
Regional Institute of Education, National Council of Educational Research Training (NCERT), Shamla Hills, Bhopal (India)
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Hydroxamic acids serve as a monsulfhydril bisubstrate analog inhibition of fernesyl protein transferase (FPT), the enzyme catalysing fernesylation of p21ras. Tumor necrosis factor (TFN) is specifically prevented by synthetic hydroxamic acid-based metalloproteinase inhibitors. Suberoyanilide hydroxamic acid (SAHA) have been identified as histone deacetylase inhibitors based on their ability to induce differentiation of cultured murine erytholeukemia cells.
KEYWORDS:Hydroxamic acid; anticancer agent
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