Three Component Solvent-Free Synthesis and Fungicidal Activity of Substituted Pyrimido [4,5-D] Pyrimidine-2-(1h)-One

Sandeep V. Shinde; Wamanrao N. Jadhav; Nandkisohr N. Karade

Article | Open Access

Three Component Solvent-Free Synthesis and Fungicidal Activity of Substituted Pyrimido [4,5-D] Pyrimidine-2-(1h)-One

Sandeep V. Shinde¹*, Wamanrao N. Jadhav¹ And Nandkisohr N. Karade²

¹Post Graduate Research Centre, Dnyanopasak College, Parbhani, 431 401 (India).

²School of Chemical Sciences, S.R.T.M. University, Nanded, 431 606 (India).

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ABSTRACT:

A novel three component condensation of aromatic aldehyde, urea or thiourea and barbituric acid or N,N-1,3-dimethylbarbituric acid was carried out using L-proline as an organo-catalyst under solvent-free microwave conditions. The resulting product, pyrimido [4,5-d] pyrimidine-2-(1H)-one was checked for the fungicide activity.

KEYWORDS:

Fungicidal acitivity; aromatic aldehyde