Application of Sodium Metaperiodate as an Oxidant for the Assay of Nebivolol in Pure State and Formulations

A.V. Subbayamma; C. Rambabu

Article | Open Access

Application of Sodium Metaperiodate as an Oxidant for the Assay of Nebivolol in Pure State and Formulations

A. V. Subbayamma¹* and C. Rambabu²

¹Department of Chemistry, St. Theresa’s College for Women, Eluru (India). ²Department of Chemistry, Acharya Nagarjuna University P.G.Centre, Nuzvid (India).

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ABSTRACT:

A simple and sensitive spectrophotometric method by exploiting the importance of the oxidation reaction of Sodium metaperiodate for the assay of nebivolol has been described. This method is based on the oxidation of nebivolol with excess of periodate and estimating the aldehyde formed with MBTH. MBTH is used to determine aromatic1,2, aliphatic and alicyclic amines3. MBTH (3-methyl-2- benzothiazolinone- hydrozone) has become an analytical tool of considerable versatility. Recoveries are almost quantitative.

KEYWORDS:

Spectrophotometric method; Nebivolol, MBTH; oxidation