Synthesis and antimicrobial activity of some novel chalcones and their related compounds

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A of chalcones have been prepared by Claisen-Schmidt condensation reaction between selected aldehyde and selected ketones. The synthesised chalcones are thiophen-2-aldehydeacetophenone (TAAP), furan-2-aldehydeacetophenone (FAAP), 2-hydroxynapthaldehyde acetophenone (HNAP), cinnamaldehydeacetophenone (CAAP), thiophen-2-aldehyde-2' hydroxy-4'methoxyacetophenone (TAHMAP), furan-2-aldehyde-2' hydroxy-4'methoxyacetophenone (FAHMAP), 2-hydroxynapth-aldehyde-2'-hydroxy-4'-methoxyacetophenone (HNHMAP), cinnam-aldehyde-2'-hydroxy-4'-methoxyacetophenone (CAHMAP), thiophen-2-aldehyde-3'-chloroacetophenone (TACAP), furan-2-aldehyde-3'-chloroacetophenone (FACAP),2-hydroxynapthaldehyde-3'-chloro-acetophenone (HNCAP), cinnamaldehyde-3'-chloroacetophenone (CACAP), The chalcones were converted into respective quinoxalines by treating them with bromine water and acetic acid and finally methanolic solution of tetramethylenediamine. All chalcones and quinoxalines have been characterised by melting point, elemental analyses and spectral studies. The antimicrobial activities of these compounds have also been studied.

Chalcones; Quinoxalines; antimicrobial activity