Synthesis of Some Quinoline Intermediates Under Phase Transfer Catalyst

Vetrivel Nadaraj¹* and Senniappan Thamarai Selvi²

¹Department of Chemistry, Tamilnadu College of Engineering Karumathampatti Post, Coimbatore- 641 029 (India). ²Department of Chemistry University Garyounis, Benghazi (Libya).

Download this article as:

ABSTRACT:

The microwave synthesis of quinoline alkaloid 4-methoxyquinolin-2(1H)-one 3a and its analogues 3b-e was achieved in 8-11 minutes by methoxydechlorinated of 4-chloroquinolin-2(1H)-ones 2a-e using TBAB as phase transfer catalyst. The starting compound obtained by selective decholorination of 1a-e by sodium acetate/acetic acid and the structure of synthesized compound has been established by IR, 1H-NMR and Mass spectral data.

KEYWORDS:

quinoline; alkaloids; acetic acid;L phase tranfer cataylst; microwave