Synthesis of some phenylpyrazolo benzimidazolo quinoxaline derivatives

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2,3-Diphenyl quinoxalin (NI) is fused with benzimidazole (NII) by a methylene bridge, which is then allowed for acetylation. The acetylated product (NIV) is made to react with different aromatic aldehydes to give chalcones (NV 1-NV 5). Chalcones refluxed with substituted acid hydrazides to afford different phenyl pyrazolo benzimidazole quinoxaline derivatives (NVI 1-NVI 15). The structure of chalcones and phenyl pyrazolo benzimidazole quinoxaline derivatives were confirmed by m.p, TLC and Spectral data. All the synthesized compounds were screened for their pharmacological activities.

Synthesis; quinoxaline; Benzimidazolo; TLC