Interaction of Some Anti Tuberculosis Drugs with Transition Metal Ions

B. K. Magare¹, M. N. Farooqui², R. S. Shelke³ and M. B. Ubale^4*

¹Shivaji Arts Comm.and Science College, Kannad Dist. Aurangabad - 431 103(India).

²Aurangabad College for Women, Navkhanda, Aurangabad - 431 001 (India).

³Pemraj Sarda College, Nagar (India).

⁴Vasantrao Naik Mahavidyalaya, Aurangabad - 431 003(India).

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ABSTRACT:

Stability constant of some transition metals like Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with pyrazinamide, isoniazid and ethambutol-HCl (22’-(1,2-Ethane dihydiimino)-bis-1-butanol) etb ,an antibacterial drugs have been evaluated at 30 o C & fixed 0.1 M (NaClO4 ) ionic strength in aqueous medium pH metrically . Proton ligand stability constants & metal ligand stability constants were determined by using Calvin Bjerrum titration technique as modified by Irving & Rossoti. Stability constants were discussed in terms of order of stability, basicity of ligands & correlated with atomic , ionization potential, electronegativity and reciprocal of ionic radii.

KEYWORDS:

Stability constant; ligands; ionic strength; basicity; antibacterial drugs etc