Synthesis of 5-(Substitutedphenyl)-{3-[4-(2-Methyl-4-(4-Hydroxy Benzylidene)-5-Oxo-Imidazol-1-Yl)]Phenyl} -Isoxazol and Study of the Antimicrobial Activities
1Department of Chemistry, Sheth L.H. Science College, Mansa - 382 845 (India).
2Department of Chemistry, Sheth M.N.. Science College, Patan - 384 265 (India).
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5-(substitutedphenyl)-{3-[4-(2-methyl-4-(4-hydroxy benzylidene)-5-oxo-imidazol-1-yl)]phenyl}-isoxazol have been prepared by the refluxation for ten hours of 4-(4-hydroxybenzylidene)-1-{4-[3-(stituted phenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one with hydroxylamine hydrochloride and 40% potassium hydroxide in presence of dioxane. The intermidiate 4-(4-hydroxybenzylidene)-1-{4-[3-(stituted phenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-(4-hydroxybenzylidene)-2-methyl-3,5-dihydro-imidazol-5-one with various aldehydes.
KEYWORDS:Synthesis; substitutedChalcones; substituted isoxazolines
