High Performance Liquid Chromatographic of Itopride Hydrochloride in Tablet Dosage Form

B. Choudhary¹, A. Goyal² and S. K. Khokra²

¹Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra - 136 119 (India).

²Bhupal Nobels College of Pharmacy, Udaipur - 313 002 (India).

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ABSTRACT:

A simple, economical, precise and fast High Performance Liquid Chromatograhic method has been developed for the determination of itopride hidrochloride in tablet dosage form. A phenomenex C18 (Luna) column of length 250× 7.5 mm with particle size of the stationary phase 5 ?m and mobile phase potassium dihydrogen phosphate buffer (pH adjusted to 7.5 with 1M Sodium hydroxide) and acetonitrile in the ratio 60:40 were used in this study. The flow rate was adjusted to 2ml /min and effluent was monitored at 258.0 nm. The proposed method describes the determination of itopride hydrochloride by HPLC, which is a simple, precise and selective.

KEYWORDS:

HPLC; Itopride hydrochloride; Domperidone