Synthesis and Biological Activity of N (Substituted) Benzylidine Ortho-Amino Benzoic Acid and N (Substituted) Benzyl Ortho-Amino Benzoic Acid

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A new series of N –(substituted) benzylidine and benzyl ortho – amino benzoic acids consisting of 12 compounds were synthesized. The use NaBH4 as a reducing agent for the reduction of N-(substituted) benzylidine ortho –amino benzoic acid to N- (substituted) benzyl ortho- amino benzoic acid appears to be new. The synthesized compounds were screened for their anti -inflammatory activity by carrageenan induced rat paw edema method. Some of these compounds have shown promising anti- inflammatory activity. ortho-amino benzoic acids are compounds with remarkable anti-inflammatory potential. These are a result of the application of classical medicinal chemistry bioisosteric drug design concepts since these derivatives are nitrogen isosteres of salicylic acid.

N –(substituted) benzylidine; benzyl ortho – amino benzoic acid