Synthesis and Antimicrobial Evaluation of 8-[{4- (2-Substituted Phenyl–5-Oxo-Thiazolidin-1-Yl)- 5-Thiobutyl Triazolo} Methoxy] Quinolines

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Synthesis and Antimicrobial Evaluation of 8-[{4- (2-Substituted Phenyl–5-Oxo-Thiazolidin-1-Yl)- 5-Thiobutyl Triazolo} Methoxy] Quinolines

T. Chandra¹, S. K. Bhati¹, H. Panwar¹and K. P. S. Vishnoi¹

¹Department of Pharmacology, L. L. R. M. Medical College, Meerut - 250 004 India. ²Department of Chemistry, K. G. College, Muradabad India.

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ABSTRACT:

Several 8-substituted derivatives of quinoline were synthesized. The structure of the prepared compounds were characterezied by elemental and spectral (I.R.,1H-NMR, Mass) analysis. These molecules were evaluated for their efficacy as antimicrobials in vitro by disc diffusion method against some selected pathogenic strains in compare to gatifloxacin and fluconazole.

KEYWORDS:

Quinolines; antibacterial activity; antifungal activity; toxicity