Synthesis and Anti-Convulsant Study of Benzylidine Rhodanine Derivatives

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Synthesis and Anti-Convulsant Study of Benzylidine Rhodanine Derivatives

Jagbir Gagoria¹,Kuldeep Singh, S. K. Jain, Gautam and Anurag Khatkar²

¹Institute of Pharmacy, Bundelkhand University, Jhansi - 284 128 India. ²Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modi Nagar India.

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ABSTRACT:

A new series of Benzylidine Rhodanine (b) have been synthesized by reaction of Rhodanine (a) and aromatic aldehydes which upon O-alkylation with different chloro- acetamides (c1- 4) form the final derivatives (d1- 4). The physical and spectral data of synthesized compounds are determined. The synthesized compounds have been screened for their anti-convulsant activity by MES method.

KEYWORDS:

Benzylidine Rhodanine; Anti-convulsant activity