Synthesis and Kinetic Perusal of Hydrolytic Severing of A Disubstituted-Aryl Phosphoric Diamide Having Antimicrobial Activity

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O-Nitro, p-chloro-phenyl Phosphoric diamide has been examined in pH range, 1.24 to 7.46 (using specific buffers to maintain each pH condition) in 12% DMSO-H2O mixture at 40 (±0.5) °C. Bimolecular hydrolysis via (a) the neutral species (I) in the low pH range 1.24-4.17 and (b) via the Monoanion species (II) in the higher pH range 5.10 - 7.46 has been established. Effects of variables like temperature, solvent strongly support the above feature. P-N bond fission has been decided by testing during progress of hydrolysis. The substrate was synthesized by the phosphorylation technique in the presence of an alkaloidal catalyst. Its antimicrobial activity is attributed to the presence of o-NO2 and p-Cl substituents in each aryl matrix.

Hydrolytic severing; antimicrobial activity