Synthesis and Biological Evaluation of S-Triazine Based Chalcones and Its Aminopyrimidine and Cyanopyridine Derivatives

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Chalones, 2,4-bis-(4'-flurophenylamino)-6-[4'-{3-(substituted phenyl/2""'-furanyl)-2""-propenon-1""-yl} phenylamino] s-triazine (6a-e) have been prepared from ketone (5) on treatment with different aromatic/hetarocyclic aldehydes. These chalcones on cyclisation with guandiine nitrate in presence of alkali and malononitrile in presence of ammonium acetate give the corresponding aminopyrimidine (7a-e) and cyanopyridine (8a-e) derivatives respectively. All the synthesized compounds have been screened for their antibacterial activity against S. aureus (MTCC 96), B. subtilis (MTCC 441), E. coli (MTCC 443) and S. paratyphi-B. (MTCC 733). The structure of the synthesized compounds have been established on the basis of their elemental analysis and spectral studies."

s-triazine; aminopyrimidine; cyanopyridine derivatives