Synthesis of Certain New Azetidin-2-one Derivatives and Comparative Study of Their Biological Activities

Chandramouli; R. H. Udupi; V. Hima Bindu

Article | Open Access

Synthesis of Certain New Azetidin-2-one Derivatives and Comparative Study of Their Biological Activities

Chandramouli1, R. H. Udupi2* and V. Hima Bindu2

¹Department of Medicinal Chemistry, NET Pharmacy College, Mantralayam, Road Raichur - 584 103 (India) ²JNT University Kukatpally, Hyderabad - 500 072 (India)

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ABSTRACT:

Aryl amines like 4-nitraniline was condensed with 2-amino-3,-dibromo benzaladehyde to get the corresponding Schiff base2. This was reacted with aryloxy acid chlorides to get the required new azetidin-2-one derivatives (3a1-a18). The compounds have been evaluated for antibacterial, antifungal, anti-inflammatory and analgesic activities. Their structures have been elucidated on the basis of elemental analysis and spectral data.

KEYWORDS:

Schiff base; aryloxy acid chlorides; azetidinones; antibacterial; antifungal; anti-inflammatory; analgesic activities