A Validation of an Hplc Method for the Determination of Ibuprofen in Presence of its Degradation Products

Rym Guelmami Chayeh¹, M. Ben Salah¹ and Rachid Chemli¹

Institut Sup

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ABSTRACT:

A rapid high performance liquid chromatographic method was developed to dose the ibuprofen in the presence of its degradations products coming from a stress treatments under different conditions of degradation (acidic, alkaline and oxidant).Its possible to dose this therapeutic molecule in presence of its degradations products if we use a C18 (SUPELCOSILTMLC-18-DB) phase column with a mobile phase ac

KEYWORDS:

ibuprofen; HPLC; validation