Synthesis of Benzimidazole Derivatives and Study of Their Antimicrobial and Antifungal Activities

Kuldeep Singh; Jagbir, Gautam; A. K. Jain; P. K. Mishra

Article | Open Access

Synthesis of Benzimidazole Derivatives and Study of Their Antimicrobial and Antifungal Activities

Kuldeep Singh*, Jagbir, Gautam, A. K. Jain and P. K. Mishra¹

¹Institute of Pharmacy, Bundelkhand University, Jhansi - 284 128 (India) ²Ayurvete Ltd. Village Katha, Post - Badi, Tehsil - Nalagarh, District Solan (India)

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ABSTRACT:

Synthesis of new benzimidazole derivatives, derived from the condensation of o-phenylenediamine & aromatic acids have been reported some of these compound have been subjected to mannich-type condensation to yield 2,3 - disubstituted benzimidazole and after methylation yield methylated derivative of 2,3- disubstituted benzimidazole. The synthesized compounds were screened for antimicrobial and antifungal activities.

KEYWORDS:

Benzimidazole derivatives; antimicrobial activity