Synthesis, Biological, Spectral and Thermal Investigations of Macrocyclic Complexes

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The complexation of new macrocyclic ligand viz., cyclo-di-thiocarbahydrazone-bis(2-hydroxy-w-(substitutedbenzoyl)-acetophenone containing substituted benzoylacetophenone unit with Cu(II) and Fe(III) has been investigated, by different spectroscopic techniques. These complexes have been characterized on the basis of elemental analyses, spectral(infrared, ESR and electronic) and thermal measurements. Molar conductance and magnetic moment measurements have also been determined. Microanalytical data revealed 1: 2 molar ratio of ligand to metal in all the complexes. The elemental analyses are consistent with the formation of the complexes [M(L)(H2O)2]Cl2[where M = Cu(II) and Fe(III); L = ligand (LI-LV)]. On the basis of electronic, EPR spectral and magnetic susceptibilities studies an octahedral geometry has been assigned for Cu(II) and Fe(III) complexes. The metal complexes were evaluated for their anti-fungal and anti-bacterial activities on the different species of pathogenic fungi and bacteria and their biopotency has been discussed. The compounds show significant inhibitory activity against bacteria and fungi.

Macrocyclic complexes; template condensation; magnetic measurements; antibacterial; antifungal; biopotency