Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-2H-Benzo[4,5]Thiazolo [2,3-C][1,2,4]Triazol-3One

S. M. Hipparagi; U. K. Majumder; L. V. G.Nargund

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Synthesis and Antimicrobial Activity of 8-Substituted-7-Fluoro-2H-Benzo[4,5]Thiazolo [2,3-C][1,2,4]Triazol-3One

S. M. Hipparagi¹, U. K. Majumder² and L. V. G. Nargund³

¹Department of Pharmaceutical Chemistry, K.L.E.S’s College of Pharmacy IInd Block Rajaji Nagar Bangalore - 560 010 (India). ²Pharmaceutical Technology Department, Jadhavpur University, Kolkata - 700 032 (India) ³Nargund College of Pharmacy, Dattatray Nagar, Bangalore - 560 085 (India)

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ABSTRACT:

We have synthesized 7-Substituted-6-fluorobenzothiazol-2-ylamine (P2) from 3-Chloro-4-fluorophenylamine. 7-substituted-6-fluorobenzothiazol-2-ylamine were treated with hydrazine hydrate to get 7-substituted-6-fluoro-benzothiazol-2-yl-hydrazine (P3) and then prepared 8-Substituted-7-fluoro-2H-benzo[4,5]thiazolo [2,3-c][1,2,4]triazol-3-one (PP 1-9) by treating ethyl chloroformate as a cyclising agent. We prepared different derivatives of this compounds its confirmed by IR, NMR. The study of antimicrobial activity reveals that the synthesized compounds have moderate activity.

KEYWORDS:

Benzothiazole; antimicrobial activity; triazinone