Microwave Assisted Synthesis of Some 2,5-Disubstituted 1,3,4-Oxadiazoles and Their Antimicrobial Activities

Anurag Khatkar*, U.K. Singh, S.K. Dewan1 Jagbir Gagoria2 and Sarita3

¹Dr. K.N.Modi Institute of Pharmaceutical Education and Research, Modi Nagar (India) ²Department of Chemistry, M.D.University, Rohtak (India) ³Institute of Pharmacy, Bndelkhand University, Jhansi (India) 3R.K.S.D. College of Pharmacy, Kaithal (India)

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ABSTRACT:

A variety of 2,5 – disubstituted 1,3,4 –oxadiazoles have been synthesized from Isoniazid and the corresponding aromatic acids both in the presence and in the absence of Mont morillonite K-10 clay catalyst. The synthesized compounds were screened for their antimicrobial activities. Better results were obtained in the presence of the catalysts.

KEYWORDS:

1;3;4-oxadiazole; microwave irradiation; antimicrobial activity