Synthesis and Characterization of Carboxamides 	of 2′-Amino-4′-(6-Chloro-3-Coumarinyl) Thiazole As Potential Nsaids

B. S. Jayashree; D. Anuradha; K.N. Venugopala

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Synthesis and Characterization of Carboxamides of 2′-Amino-4′-(6-Chloro-3-Coumarinyl) Thiazole As Potential Nsaids

B. S. Jayashree¹*, D. Anuradha² and K. N. Venugopala¹

¹Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore - 560 027, Karnataka (India) ²Department of Pharmaceutical Chemistry, Kamala Nehru Polytechnic for women and Sarojini Naidu Pharmacy Maha Vidyalaya, Hyderabad (India)

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ABSTRACT:

A series of carboxamides of 2'-amino-4'-(6-chloro-3-coumarinyl) thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, 1H-NMR and mass spectral (MS) studies and were evaluated for their analgesic and anti-inflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few test compounds showed significant analgesic and anti-inflammatory activity.

KEYWORDS:

Carboxamides; aminothiazolyl coumarin; analgesic; anti-inflammatory activity