Determination of Some Diuretics With Pyridinium Flurochromate (PFC) Reagent

P. K. Dwivedi; Santosh Kumar; B. K Singh; I. C.Shukla

Article | Open Access

Determination of Some Diuretics With Pyridinium Flurochromate (PFC) Reagent

P. K. Dwivedi, Santosh Kumar, B. K Singh and I. C. Shukla

Department of Chemistry, University of Allahabad, Allahabad - 211 002 (India)

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ABSTRACT:

A simple and conventient method has been developed for the milligram determination of some diuretics e.g. Acetazolamide, Frusemide, Spironolactone, Hydrochlorothiazide, Indapamide hemihydrate and Mannitoal in pure form and in their pharamaceutical preparations with the use of Pyridinium Flurochromate (PFC) in acidic medium. The values of % error, SD and CV prove the method to be precise and reproducible.

KEYWORDS:

Diurtetics; Pharamaceutical; PFC; Iodometry