Synthesis and Antimicrobial Activity of 2- Acetoxy Substituted Phenyl Pyrazolines in Triethanolamine Medium


P.S. Utale*, R. D. Urkude, V. K. Yeotikar and A. G. Doshi  
Department of Chemistry, Science College, Congress Nagar, Nagpur - 440 012 (India)

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ABSTRACT:

2- Acetoxy Chalcone and aqueous solution of hydrazine hydrate were refluxed in Triethanolamine for 2 hrs. The reaction mixture was cooled,filtered and crystallised from ethanol-acetic acid mixture to get 3 (2-Acetoxy - 5 - Chlorophenyl ) 1- H - 5 - Phenyl -D2- Pyrazolines. All these synthesised new pyrazolines were tested against organisms. The Minimum Inhibitory Concentration ( MIC ) values were determined by using serial dilution method.

KEYWORDS:

Synthesis; Pyrazolines; Derivatives


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