Synthesis and Characterization of Phenothiazinothiadiazole and Study of Their Antibacterial and Antifungal Activities

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Several 2-(substituted)amino- (N10 phenothiazino methyl)-1,3,4-thiadiazoles 4 has been synthesized and tested for antibacterial and antifungal activities. The structure of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data. Phenothiazine on the treatment with ethylchloroacetate afforded ethyl N10-phenothiazino acetate 1. Which on reaction with thiosemicarbazide resulted in the formation of N10-phenothiazino-acetylthiosemicarbazide 2. The compound 2 with conc. H2SO4 yielded the thiadiazole 3. Which on condensation with various selected carbonyl compound furnished 2-(substituted) amino- (N10 phenohiazino methyl methyl)-1,3,4-thiadiazoles 4(a-e).

Phenothiazinothiodiazole; Antifungal activities