Synthesis and Antibacterial Activity of Some New Fluorosubstituted Pyrazolines, Isoxazolines and Pyrimidines

Anjani Solankee; Kishor Kapadia; Indrajit Thakor; Jayesh Patel; Smruti Lad

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Synthesis and Antibacterial Activity of Some New Fluorosubstituted Pyrazolines, Isoxazolines and Pyrimidines

Anjani Solankee*, Kishor Kapadia, Indrajit Thakor, Jayesh Patel and Smruti Lad

Department of Chemistry, B.K.M. Science College, Valsad- 396 001 (India)

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ABSTRACT:

Some fluoro substituted pyrazolines, isoxazolines and pyrimidines have been synthesised from chalcone on reaction with hydrazine, hydroxylamine and guanidine respectively. Structure of these compounds have been established on the basis of spectral studies and elemental analysis. All the synthesised compounds have been screened for their antibacterial activities against S. aureus, E. coli, S. paratyphi-A and B. subtilis.

KEYWORDS:

Pyrazolines; Isoxazolines; Pyrimidines; Antibacterial activity