Synthesis and Biological Activities of Some 4-Thiazolidinones Derivatives

A. K. Bhatt, Viraj R. Sanghvi, M. P. Parmar, P. R. Shah, Hasan Ali K. and H. D. Patel

Chemistry Department, St. Xavier's College, Ahmedabad- 380 009 (India)

Download this article as:

ABSTRACT:

Various 4-Oxothiazolidinones III(a-j) were prepared by reacting N-[1-aza-2-(substituted phenyl)] (2-acetamido 5-bromo phenyl) carboxamides II (a-j) with thioglycolicacid. Reaction between N-amino (2-acetamido 5-bromo phenyl) carboxamide I and different aldehydes gives N-[(1-aza-2-(substituted phenyl)] (2-acetamido 5-bromo phenyl) carboxamides II (a-j). These compounds were characterized on the basis of elemental and spectral analysis. All the newly synthesized compounds were tested for their antibacterial activity.

KEYWORDS:

4-Oxothiazolidinones derivatives