Synthesis and Antimicrobial Activity of Some New N-(4-N or N,N-Disubstituted Amino Sulfonyl Phenyl)-3-Chloro-4-Phenyl Azetidine-2-Ones

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Various 4-benzylideneazanyl-N or N,N-disubstituted benzene sulfonamides (3a-j) have been prepared by condensation of 4-amino-N- or N,N-disubstuted benzene sulfonamide (2) with benzaldehydes. These on cyclocondensation reaction of (3a-j) with chloroacetylchloride afforded N-(4-N or N,N-disubstituted amino sulfonyl phenyl)-3-chloro-4-phenyl azetidine-2-ones (4a-j). Biological screening of the prepared compounds have been carried out on some strains of bacteria.

N;N-disubstituted benzene sulfonamides; cyclocondensation; azetidine