Synthesis of N-Substituted Phenyl-4-Thiophenyl-2-Azetidinones and its Antimicrobial Activity

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2-Thiophenylidine-substituted aniline condenses with acetyl chloride in presence of triethyl amine in benzene gives N-substituted phenyl-4-thiophenyl-2-azetidinones. The azetidinones structure were confirmed by spectral and chemical data. These azetidinones tested against test organism Staphylococcus aureus, Bacillus megatherium, Bacillus subtilis, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and MIC values are obtained by serial dilution method. Title compound were found effective against both Gram positive and Gram negative bacteria. The minimum inhibitary concentration (MIC) value are in the range of >3 to 200 μg/ml for both Gram positive and Gram negative bacteria.