Synthesis and Antibacterial Activity of Some 2-Azetidinone Derivatives

K. G. Ojha; Neera Jaisinghani; Rashmi Upadhyay

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Synthesis and Antibacterial Activity of Some 2-Azetidinone Derivatives

K. G. Ojha*, Neera Jaisinghani and Rashmi Upadhyay

Department of Applied Chemistry, M.D.S. University, Ajmer – 305 009 (India)

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ABSTRACT:

Substituted 1-Benzothiazolyl-4-aryl-azetidinones (III) have been prepared by the condensation of substituted 2-aminobenzothiazoles(I) with salicylaldehyde followed by reaction with acetyl chloride in presence of triethylamine in dioxane. The synthesized compounds were screened for the antibacterial activities against E.coli, S. aureus, P. mirabilis, Pseudomonas and Klebsiella spp.

KEYWORDS:

2-Azetidinones; Salicyldehyde; Antibacterial activity