Chemical Homology and Phylogenetic Divergence of Certain Animal Cytotoxins

R. K. Upadhyay

Laboratory of Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi -110 067 India.

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ABSTRACT:

Computer analysis was applied to study conserved and consensus sequences of several cytotoxins of different animals groups. A conserved domain DKCN and conserved sequences C, N, H, P, K and RG are analysed. Most of the toxins have the C terminal conservation site with high diversity of action mechanism. Evolutionary tree was constructed which shows species specific interaction and allows division of each family into sub -families.

KEYWORDS:

cytotoxins; DKCN; Evolutionary tree