Synthesis of Naphth-1,2,5-Oxathiazine  Derivatives of Biological Interest

Nabaweya Sharaf El-Din; Eatedal Hassan

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Synthesis of Naphth-1,2,5-Oxathiazine Derivatives of Biological Interest

Nabaweya Sharaf El-Din¹ and Eatedal Hassan²*

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy,University of Tanta, Tanta Egypt.

²Department of Orgh'anic Chemistry, Faculty of Pharmacy, University of Zagazig Egypt.

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ABSTRACT:

Naphth-1,2,5-oxathiazine derivatives were synthesized via the cyclizatibn of 2-afrifKHiapritfiafenesulfoTiic acid with various acid anhydrides, carboxylic acids or aldehydes under the acidic conditions. The most of prepared compounds showed the interesting antibacterial activity.

KEYWORDS:

2- Aminonaphthalene sulfonic acid; naphthoxathiazine derivatives; antibacterial activity; diuretic activity