Synthesis of Some Newer Potent Antiinflammatory Substituted Phenothiazines

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Twenty new phenothiazine derivatives were synthesized and screened against carrageenin induced oedema in albino rats. Almost all the compounds have shown promising anti-inflammatory activity, compound 4e' i.e. 10-[2-(3'-chloro-2'-oxo-4,-o-methoxypheny|-1,-azetidinyl)-4-oxazolyl] phenothiazine was found to be most potent The most potent compound was evaluated for its antiinflammatory potency, ulcerogenic lability and scute toxicity. It was found more potent than the standard drug, phenylbutazone.

phenothiazine; carrageenin; antiinflammatory potency; ulcerogenic