Susceptibility Study (in Vitro) of Antibacterial Agents Against Drug Resistant Mycobacterium Tuberculosis

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The antibacterial activity of 23 antibacterial agents against a susceptible and two multidrug resistant strains of Mycobacterium tuberculosis were compared in vitro by agar dilution method. The multidrug resistant strain MDR-I was found resistant to isoriiazid, streptomycin and rifampin while MDR-II was resistant to pyrazinamide and thiacetazone. The MICs of chloro derivatives of sufphaphenazol and thiocarbamide were lower than the parent compounds for both resistant strains under study.

Mycobacterium; ufphaphenazol; Ntibacterial; lower