Mannich Reaction of Pyrazole Leading to Alcohol and the Central Depressant Activity of the Product

Talal A.K.AI-Allaf; Luay J. Rashan; Adnan S. Abu-Surrah

Article | Open Access

Mannich Reaction of Pyrazole Leading to Alcohol and the Central Depressant Activity of the Product

Talal A. K. AI-Allaf¹, Luay J. Rashan² and Adnan S. Abu-Surrah³

¹Department of Chemistry, Faculty of Science,

²Department of Pharmacology, Faculty of Pharmacy, Applied Science University, Amman -11931 ^(Jordon)

^{3Anorganische} Chemie II, Universitat, Ulm, D-89069, Ulm, (Germany)

Download this article as:

ABSTRACT:

Mannich reaction of 3,5-dimethyipyrazole using paraformaldehyde, copper (I) chloride and glacial acetic acid in dioxane, leads to the formation of 3,5-dimethylpyrazole-1-yl-methanol as an Intermediate product. The latter surprisingly does not proceed further upon its reaction with propargyl acetate in order to form the 2-butynyl derivative. The product has been fully characterized and assigned and its formation's mechanism has been given and discussed. The central depressant activities of the product and its pyrazole starting material have been demonstrated In mice and compared with that of the references standard tegretol.

KEYWORDS:

Paraformaldehyde; Intermediate; Surprisingly; pyrazole