Synthesis and Antimicrobial Activity of 2-(Substituted Benzylidene)-6, 7 Benzo C0umaran-3-0ne and its Dibromide

V. B. Kadu* and A. G. Doshi

Department of Chemistry, Shri Shivaji Science College, Morshi Road, Amravati 444 602 India.

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ABSTRACT:

2'-Hydroxy-3,4'benzo - substituted chaIcons (la-d) were taken in DMSO and mercuric acetate was added to it. The reaction mixture was refluxed for 2-3 hrs. and then diluted with water. The solid separated was crystallised from rectified spirit to give substituted aurone (lla-d). Substituted aurone (lla-d) on bromination gave substituted aurone dibromide (llla-d). These compounds are tested against test organism Staphylococcus aureus, Salmonella typhi, E coli, Proteus mirabilis, Klebsiella pneumonia and Shigella dysentariae. Activity of these compounds were compared with standard drug chloramphenicol. MIC values by serial dilution method16.

KEYWORDS:

Antimicrobial; 2-(Substituted Benzylidene)-6; Crystallised; Salmonella